The International Railway Safety Conference (IRSC) is a forum that brings together rail safety professionals from around the globe in order to exchange information and provide experiences and lessons for improving rail safety and is exclusively devoted to rail safety issues. IRSC 2010–the 20th annual meeting–will be held in Hong Kong 3-8 October 2010 under the theme “Challenges in Sustaining Railway Safety.” Online registration is open for the second-stage early bird discount. Abstracts for presentations are being accepted through 30 June 2010.